Carl read the papersWhat it actually is
LL-37 is a naturally-occurring human cathelicidin that disrupts microbial membranes and breaks down biofilms.
It also tunes the immune response and supports tissue repair near the injection site.
How it’s thought to work
- Membrane disruption — broad antimicrobial (bacteria/fungi/virus).
- Biofilm breakdown — why people try it for stubborn gut/sinus infections.
- Immunomodulation — recruits immune cells, tunes inflammation.
- Pro-angiogenic — wound-healing signalling locally.
What the research says
Strong basic-science/preclinical data on its antimicrobial and immune roles; essentially no human injectable-supplement trials — all community use is off-label/anecdotal. Not approved.
- Gut/biofilm infection research (anecdotal).
- Immune modulation & wound healing.
- Product authenticity is the #1 concern.
Reported protocols
These are the doses the peptide community actually reports running (Reddit & forums), alongside published research — logged for education, not as a recommendation to use.
| Parameter | Commonly reported range |
|---|---|
| Community dose | ~100 mcg most common (some run higher-mg — often distrusted as mislabeled) |
| Frequency | Daily short course; some 2–3×/week |
| Route | SubQ (near-site for local/gut targets) |
| Cycle | Short — ~2–3 weeks, not continuous |
| Community tip | Start low — LL-37 can trigger a strong histamine/herx-like flare as it kills off biofilm |
Common use cases
| Goal | Community protocol notes |
|---|---|
| Stubborn gut/biofilm issues | ~100 mcg daily, 2–3 wks, near-site |
| Immune / inflammation support | short course |
| (Caution) | MCAS/histamine-reactive users — go very low |
Mixing it (reconstitution)
Freeze-dried peptides must be reconstituted with bacteriostatic water before they can be measured. Carl’s calculator turns “mg in the vial + ml of water + target dose” into “units on the syringe” — and tells you how long the vial lasts.
→ Open the Reconstitution Calculator
Injection & handling
SubQ in short courses; inject near the target region (e.g. lower abdomen for gut) when practical. Expect a possible flare — start low. Refrigerate reconstituted, use within ~28 days.
Stacks it appears in
- Gut Support — LL-37 + KPV / BPC-157 — layered gut-inflammation angles.
