Carl read the papersWhat it actually is
Sermorelin is a 29-amino-acid analog of GHRH — historically used in medicine to test and support GH production, including in children with growth issues.
It has a longer clinical history than newer analogs, though it’s shorter-acting, so it’s often dosed nightly to mirror natural GH pulses.
How it’s thought to work
- GHRH mimicry — stimulates the pituitary to release GH.
- Preserves rhythm — supports natural pulsatile GH rather than replacing it.
- Nightly timing — often dosed at bedtime to match GH peaks.
What the research says
Has genuine clinical/diagnostic history and was FDA-approved in the past (later discontinued commercially). Anti-aging and wellness use today is off-label.
- Supports natural GH output.
- Sleep, recovery and body-composition goals (reported).
- Historically used as a GH-deficiency diagnostic.
Reported protocols
These are the doses the peptide community actually reports running (Reddit & forums), alongside published research — logged for education, not as a recommendation to use.
| Parameter | Commonly reported range |
|---|---|
| Community dose | Clinic 200–300 mcg; community pushes 500 mcg–1 mg nightly (start 100–200) |
| Frequency | Once daily, at night |
| Route | Subcutaneous |
| Cycle | Nightly; judge over 3+ months |
| Community tip | Inject fasted before bed — carbs/insulin blunt the GH release |
Common use cases
| Goal | Community protocol notes |
|---|---|
| GH support | 500 mcg–1 mg nightly, fasted |
| Sleep & recovery | bedtime timing |
| Judge over time | give it 3+ months |
Mixing it (reconstitution)
Freeze-dried peptides must be reconstituted with bacteriostatic water before they can be measured. Carl’s calculator turns “mg in the vial + ml of water + target dose” into “units on the syringe” — and tells you how long the vial lasts.
→ Open the Reconstitution Calculator
Injection & handling
SubQ at night, fasted before bed — carbs/insulin blunt the GH release. Clinic dose is 200–300 mcg; the community often runs 500 mcg–1 mg nightly. Refrigerate reconstituted.
Stacks it appears in
- Classic GH — Sermorelin + Ipamorelin — an alternative to the CJC pairing.
